Acroerythrokeratoderma also called Mal de Meleda, is a rare genetic skin disorder where the hands and soles of feet become hard and callused. This condition begins in infancy and usually gets worse with time. This disorder is passed down from parent to child in an autosomal recessive manner, which means both parents need to have at least one copy of the changed gene to pass it down to their child.
Most often people with Mal de Meleda have thick skin on the palms, hands, feet, wrists, ankles, joints, and fingers. Short fingers and toes, red skin around the mouth, repeat fungal infections, and excessive sweating are also commonly reported. A doctor may observe these symptoms, along with an individual's family history in order to diagnose this disorder. There are many different treatments to help those with Mal de Meleda, including oral medicines and skin creams.
If you have been diagnosed with Mal de Meleda, talk with your doctor about the most current treatment options. Support groups are also good resources of support and information.
Description Last Updated: Jun 14, 2018