Huntington disease-like 2 is a genetic condition caused by a change in the NPH3 gene. Genes control the growth, development, and function of the body. A change (mutation) in the gene can cause it to not work properly. Each person has two copies of every gene, one from the mother and one from the father. Huntington disease-like 2 is passed down from parent to child in an autosomal dominant manner, meaning only one mutation from one parent is inherited by a child in order to cause symptoms. A person with this condition has a 50/50 chance of passing the condition on to their children.
Huntington disease-like 2 is similar to Huntington disease. The condition affects brain functions, which can create changes in behavior, personality, or memory. Huntington disease-like 2 affects the ability to move, especially coordination and involuntary movements. This often happen during mid-adulthood and can worsen as someone gets older. Other symptoms include inability to walk, speak, or swallow. If you or a family member has been diagnosed with Huntington disease-like 2, talk with your doctor about the most current treatment options as well as signs that you may need immediate medical attention.